Osteoarthritis. Osteoarthritis, unspecified site
Conditions
Interventions
Intervention 1: Intervention group: Patients with knee OA who take melatonin in addition to their previous treatment. In the first week 3mg daily, second week 5mg daily and then 10mg daily until the e
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
35 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with diagnosis of grade 1 and 2 knee of Osteoarthritis Lack of other inflammatory diseases No other drugs used except NSAIDs Lack of neuralgic and psychiatric illnesses
Exclusion criteria
Exclusion criteria: Patients who find it difficult to participate in the trial Patients for whom the drug treatment phase was not responsive, and should undergo surgery Patients who are allergic to melatonin Patients who suffer from R.A Patients with a history of cardiac arrhythmia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WOMAC QUESTIONERS SCORE. Timepoint: The beginning of the study (before the start of the intervention) and the week12 After starting to take melatonin. Method of measurement: WOMAC QUESTIONERS.;KOOS QUESTIONERS SCORE. Timepoint: The beginning of the study (before the start of the intervention) and the week12 After starting to take melatonin. Method of measurement: KOOS QUESTIONERS. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyyed Mohammed Tahami
Shiraz University of Medical Sciences
Outcome results
None listed