Essential Hypertesion. Essential (primary) hypertension
Conditions
Interventions
Intervention 1: Intervention 1: Captophyte compound divided in two equal 2g doses of red algae and combined with captopril 25 mg tablets in a capsule (Captophyte capsule) three times daily for 28
Treatment - Drugs
Intervention 1: Captophyte compound divided in two equal 2g doses of red algae and combined with captopril 25 mg tablets in a capsule (Captophyte capsule) three times daily for 28 days.
Control group: 25 mg captopril combined with placebo (from DANA pharmaceuticals) is used for 28 days
Sponsors
Vice Chancellor for Research & Technology, Hormozgan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 55 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: essential hypertension; age of 20 - 55 years and no response to diet and exercise in prehypertension state. Exclusion criteria: one or more of the following: Creatinine levels > 1.5 mg/dl; elevated liver enzymes; intake of any of the anti-hypertensive medications (nitrates, beta blockers, anhydrase carbonic inhibitors, calcium channel blockers, diuretics and angiotensin receptor blocker) due any other underlying medical causes; concurrent intake of any medications having hepatic metabolism (with super enzymes of cytochrome p450 including CYP2D6 (i.e. imipramine, fluoxetine, promethazine, celcoxib, hydroxyzine, citalopram, dextrometorphan, codeine, ondansetron, tamoxifen, tarmadol ). CYP3A4 (clarythromycin, erythromycin, cimetidine, carbamazepine, phenytoin, phenobarbital, rifampin, corticosteroids, atorvastatin, benzodiazepines, and haloperidol) which metabolize most of BB, CCB, ACEI, ARB; medication with warfarin; other cardiovascular complications such as angina pectoris, IHD, hypertensive crisis, or cerebrovascular accidents such as TIA, or stroke which require CCB, BB, ACE; GI disturbances; allergic reactions; immunologic reactions; unwillingness to participate in the study; death of the patient.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure. Timepoint: Every week for 28 days. Method of measurement: Measuring blood pressure with mercury sphygmomannometer. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Seyedeh Tasnim Eghbal Eftekhaari
Hormozgan University of Medical Sciences
Outcome results
None listed