Knee osteoarthritis. Gonarthrosis
Conditions
Interventions
Intervention 1: Chamomile flower extract in sesame oil, three times a day, topically on the more painful knee. Intervention 2: Diclofenac 1% topical gel, three times a day on the more painful knee. In
Treatment - Drugs
Placebo
Chamomile flower extract in sesame oil, three times a day, topically on the more painful knee
Diclofenac 1% topical gel, three times a day on the more painful knee
Liquid Paraffin, topically, three times a day on the more painful knee
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
38 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: the age between 38-65 years; patient's written informed consent for inclusion; recognition of osteoarthritis by the physiatrist according to American college of rheumatology classification criteria; recognition of grade I to III by the physiatrist osteoarthritis according to Kellegren-Lawrence system of classification. Exclusion Criteria: those who need more than 2 grams of acetaminophen per day; those who need to use other oral or intravenous analgesic; unwillingness to continue to participate in the study; sensitivity to study drugs; patients with other bone joint disorders like rheumatoid arthritis, gout, pseudo gout, infected arthritis, metabolic arthritis, traumatic arthritis, joint replacement, fibromyalgia, non-motor dysfunction related to hip or knee (radiculopathy and neuropathy); concomitant use of glucosamine and chondroitin sulfate; knee corticosteroid injection in the past 3 months; other articular corticosteroid injection in the past 1 month; taking muscle relaxant drugs; pregnancy; oral and local use of corticosteroid in 14 past days; muscle corticosteroid injection in the past 1 month; alcohol addicted; drug abuse; skin diseases in knee; patients with active renal, liver and peptic ulcer diseases; disability to cooperate in filling the forms (cognitive or language disorder).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: At the beginning of intervention and after 1 week, 2 weeks and 3 weeks after the beginning of intervention. Method of measurement: WOMAC questionnaire.;Joint stiffness. Timepoint: At the beginning of intervention and after 1 week, 2 weeks and 3 weeks after the beginning of intervention. Method of measurement: WOMAC questionnaire.;Function. Timepoint: At the beginning of intervention and after 1 week, 2 weeks and 3 weeks after the beginning of intervention. Method of measurement: WOMAC questionnaire.;The need for acetaminophen 500 milligrams tablets. Timepoint: 1 week, 2 weeks and 3 weeks after the beginning of intervention. Method of measurement: Asking from patients. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Ruhollah Shoara
Shiraz University of Medical Sciences
Outcome results
None listed