The effect of anesthetic agents on electroshock In patients with treatment-resistant major depression

Comparison of effect of anesthesia with ketamine or thiopental during electro-shock in patients with treatment-resistant major depression

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015013012642N13

Enrollment

160

Registered

2015-02-20

Start date

2014-03-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Treatment-resistant depression. Severe depressive episode with psychotic symptoms

Interventions

Intervention 1: first group: treatment-resistant depressed patients are anesthesied with ketamine with dose of 0.8 mg per killogeram was used in Ect. Intervention 2: second group: treatment-resistant

Prevention

first group: treatment-resistant depressed patients are anesthesied with ketamine with dose of 0.8 mg per killogeram was used in Ect.

second group: treatment-resistant depressed patients are anesthesied with thiopental with dose of 1.5 mg per killogeram was used in Ect.

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: inclusion criteria: age between 20 to50 years old; refractory depression According to the psychiatrist diagnosis. exclusion criteria: Any physical illness such as cardiovascular-cerebrovascular disease; high intracranial pressure; glaucoma; high eyes pressure; uncontrolled high blood pressure; Arterial Aneurysm; Previous history of alcohol and drug use; The occurrence of myocardial infarction in the last three months; Failure to ECT in the past month

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Depression. Timepoint: After completion of each stage of the ECT and Gained consciousness. Method of measurement: evaluation is based on the Hamilton test Depression.;Seizure time. Timepoint: After completion of each stage of the ECT and Gained consciousness. Method of measurement: According to an electrical timer in seconds.	—

Secondary

Measure	Time frame
Herat rate. Timepoint: After completion of each stage of the ECT and the conscious patient. Method of measurement: By pulse oximetry in terms of the number of minutes.;Blood pressure. Timepoint: After completion of each stage of the ECT and the conscious patient. Method of measurement: Manometer gauge in mmHg.	—

Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026