Comparison between two drugs, Mefenamic acid and Tranxamic acid for the treatment of menorrhagia due to IUD

Comparison between the efficacy of Mefenamic acid and Tranxamic acid in control of menorrhagia in IUD users in coverage area of Shahid Beheshti University

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015012612494N3

Enrollment

450

Registered

2015-03-04

Start date

2012-07-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Excessive, frequent and irregular menstruation. Noninflammatory disorders of female genital tract

Interventions

Intervention 1: Control: The first group take two 250 mg capsule of Mefenamic Acid three times a day. Intervention 2: Intervention: The second group take 500 mg tranexamic acid tablets or capsules thr

Treatment - Drugs

Control: The first group take two 250 mg capsule of Mefenamic Acid three times a day.

Intervention: The second group take 500 mg tranexamic acid tablets or capsules three times a day.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Inclusion criteria? Patients should be eligible for IUD insertion accordance to state protocol? And after IUD insertion? they have long more than 7 days of menstrual bleeding and menstural volume are greater than 80 cc. Exclusion criteria? Patients with anatomical abnormalities such as uterine myoma and adenomyosis? coagulopathies? anticoagulant therapy and genital infection and endometritis and other confounding factors can lead to increased bleeding.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Volume of blood loss. Timepoint: Three monthes after start of intervention. Method of measurement: Qulify amount of bleeding on sanitary napkin.;Number days of bleeding. Timepoint: Three monthes after start of intervention. Method of measurement: Questionare.;Sequence of bleeding. Timepoint: Three monthes after start of intervention. Method of measurement: Questionare.	—

Secondary

Measure	Time frame
Hemoglobin concentration. Timepoint: Before and three monthes after treatment. Method of measurement: Labratory investigation.;Hematocrit concentration. Timepoint: Before and three monthes after treatment. Method of measurement: Labratory investigation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNasrin Saharkhiz

Infertility & Reproductive Health Research Center Shahid Beheshti University of Medical Science

saharkhiz1377@yahoo.com+98 21 2243 2558

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026