Impact of resveratrol supplementation in treatment of periodontal patients with type 2 diabetes mellitus

Impact of resveratrol supplementation on periodontal indices, antioxidant status, inflammatory markers and blood sugar in periodontal patients with type 2 diabetes mellitus

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015012420765N1

Enrollment

Registered

2015-03-29

Start date

2015-02-04

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Impact of resveratrol supplementation on periodontal status, antioxidant, inflammatory periodontal disease and high blood sugar in type 2 diabetes. Non-insulin-dependent diabetes mellitus

Interventions

Intervention 1: Intervention: The intervention group receive resveratrol supplement (500 mg as capsulated) for 4 weeks. Intervention 2: control: the control group receive placebo capsules containing w

Placebo

Intervention: The intervention group receive resveratrol supplement (500 mg as capsulated) for 4 weeks.

control: the control group receive placebo capsules containing wheat flour (500 mg) for 4 weeks.

Eligibility

Sex/Gender

All

Age

30 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Males and females aged (30 – 60 y); type 2 diabetic patients (at least 5 years of diagnosis) with chronic periodontal disease; BMI = 18.5 < 30kg/m2 Exclusion criteria: Diabetic complications such as renal failure; using insulin therapy; pregnancy; breast feeding; traveling greater than 1 weeks; smoking; using any dietary supplements including antioxidant supplements; using immunosuppressive medications; history of periodontal therapy; following specific diet; changing usual diet and planning to weight loss

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
IL-6. Timepoint: Before and after the intervention. Method of measurement: Elisa.;Fasting blood sugar. Timepoint: Before and after the intervention. Method of measurement: Using enzymatic kits.;Total antioxidant capacity of blood. Timepoint: Before and after the intervention. Method of measurement: Elisa.;Bleeding during probe. Timepoint: Before and after the intervention. Method of measurement: Evaluation of bleeding.;Plaque index. Timepoint: Before and after the intervention. Method of measurement: Plaque is on the tooth surface.;Pocket dept. Timepoint: Before and after the intervention. Method of measurement: The probing depth is measured by the probe.;Clinical attachment level. Timepoint: Before and after the intervention. Method of measurement: Depth study of cement and enamel plaque periodontal.;TNF-a. Timepoint: Before and after the intervention. Method of measurement: Elisa.	—

Measure

Time frame

IL-6. Timepoint: Before and after the intervention. Method of measurement: Elisa.;Fasting blood sugar. Timepoint: Before and after the intervention. Method of measurement: Using enzymatic kits.;Total antioxidant capacity of blood. Timepoint: Before and after the intervention. Method of measurement: Elisa.;Bleeding during probe. Timepoint: Before and after the intervention. Method of measurement: Evaluation of bleeding.;Plaque index. Timepoint: Before and after the intervention. Method of measurement: Plaque is on the tooth surface.;Pocket dept. Timepoint: Before and after the intervention. Method of measurement: The probing depth is measured by the probe.;Clinical attachment level. Timepoint: Before and after the intervention. Method of measurement: Depth study of cement and enamel plaque periodontal.;TNF-a. Timepoint: Before and after the intervention. Method of measurement: Elisa.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactRazie Hormoznejad

Ahvaz Jundishapur University of Medical Sciences

r_hormozi68@yahoo.com+98 74 3333 1257

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026