Comparison of the effects of anesthesia level of fentanyl and remifentanil in intensive care unit patients

Comparison of the effects sedation induced by fentanyl and remifentanil in patients under mechanical ventilation in the intensive care unit

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015012311398N8

Enrollment

Registered

2015-02-06

Start date

2014-08-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mechanical ventilation. Other specified medical care

Interventions

Intervention 1: Remifentanil, 3 µg/kg/hr, intravenous injection, made in Normon company, Spania. Intervention 2: Fentanyl, 1 µg/kg/hr, intravenous injection, made in Aboo-Reyhan company, Iran.

Treatment - Drugs

Remifentanil, 3 µg/kg/hr, intravenous injection, made in Normon company, Spania.

Fentanyl, 1 µg/kg/hr, intravenous injection, made in Aboo-Reyhan company, Iran.

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age over 18 years old; Neurosurgical intensive care unit patients who need mechanical ventilation in the first 24 hours before or after neurosurgery; Stable hemodynamic. Exclusion criteria: Neuromuscular diseases; History of taking neuromuscular blocker medications; Pregnancy; Opium addiction.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Sedation level. Timepoint: Every 2 hours in the first 6 hours and then every 6 hours since the first 24 hours. Method of measurement: Sedation scale.;Ventilation duration. Timepoint: Since ventilation to the time removing the device from the patient. Method of measurement: Chronometer.;Blood pressure. Timepoint: Every 2 hours in the first 6 hours and then every 6 hours since the first 24 hours. Method of measurement: Sphygmometer.;Heart rate. Timepoint: Every 2 hours in the first 6 hours and then every 6 hours since the first 24 hours. Method of measurement: Monitoring.	—

Measure

Time frame

Sedation level. Timepoint: Every 2 hours in the first 6 hours and then every 6 hours since the first 24 hours. Method of measurement: Sedation scale.;Ventilation duration. Timepoint: Since ventilation to the time removing the device from the patient. Method of measurement: Chronometer.;Blood pressure. Timepoint: Every 2 hours in the first 6 hours and then every 6 hours since the first 24 hours. Method of measurement: Sphygmometer.;Heart rate. Timepoint: Every 2 hours in the first 6 hours and then every 6 hours since the first 24 hours. Method of measurement: Monitoring.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Sadat Mazhari

Iran University of Medical Sciences

fmazhari.md@gmail.com+98 21 8670 2503

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026