L-arginine supplementation effect on CVDs.

Effect of L-arginine supplementation on biochemical and anthropometirc indices associated with cardiovascular diseases

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201501183236N6

Enrollment

Registered

2015-02-01

Start date

2015-01-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity. Obesity, unspecified

Interventions

Intervention 1: L-Ariginine 3 g/day 8 weeks. Intervention 2: L-arginine 6 g/day 8 weeks. Intervention 3: placebo 8 weeks.

Treatment - Drugs

Placebo

L-Ariginine 3 g/day 8 weeks

L-arginine 6 g/day 8 weeks

placebo 8 weeks

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: both sexes; BMI higher than than 29.9 kg/m2 or visceral obesity (BMI whithin25- 29.9 kg/m2 and wc more than 102 cm in men or more than 88 in women); acute or chronic inflammation; stable body weight 3 months before the start of the study (based on self report) absence of any current diet or supplement treatment; absence of antidiabetic, antihypertensive, antihyperlipidemic treatment; no history of ischemic heart disease; and normal renal and liver function. Exclusion criteria: Unwillingness to continue; the use of tobacco or alcohol during the study; taking any supplements other than the selected intervention; any disease or physiological changes that requires special treatment; failure to follow the intervention designing (not consuming dedicated supplement to the total amount less than 90% predicted or more than 3 days).

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Weight. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: Balance - kg.;Wc. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: Tape - cm.;Skinfold. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: caliper - mm.;Systolic and diastolic blood pressure. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: Pressure set manually - mm Hg.;Fbs. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: Standard enzymatic method - milligrams per deciliter.;TG. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: Standard enzymatic method - milligrams per deciliter.;TC. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: Standard enzymatic method - milligrams per deciliter.;LDL. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: Standard enzymatic method - milligrams per deciliter.;HDL. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: Standard enzymatic method - milligrams per deciliter.;HbA1c. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: Standard enzymatic method - percentage.;MDA. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: Standard enzymatic method - micromol per liter.	—

Measure

Time frame

Weight. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: Balance - kg.;Wc. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: Tape - cm.;Skinfold. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: caliper - mm.;Systolic and diastolic blood pressure. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: Pressure set manually - mm Hg.;Fbs. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: Standard enzymatic method - milligrams per deciliter.;TG. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: Standard enzymatic method - milligrams per deciliter.;TC. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: Standard enzymatic method - milligrams per deciliter.;LDL. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: Standard enzymatic method - milligrams per deciliter.;HDL. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: Standard enzymatic method - milligrams per deciliter.;HbA1c. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: Standard enzymatic method - percentage.;MDA. Timepoint: Before the experiment, eight weeks after intervention. Method of measurement: Standard enzymatic method - micromol per liter.

—

Secondary

Measure	Time frame
BMI. Timepoint: Before and after intervention. Method of measurement: weight devide into height2.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactArash Dashtabi

Shiraz University of Medical Sciences, Faculty of Nutrition and Food Sciences

arash.dashtabi@yahoo.com+98 71 3725 1001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026