metabolic acidosis. An abnormal increase in the acidity of the body's fluids
Conditions
Interventions
Intervention 1: Treatments in intervention group included trinitroglycerin 0.1 µg/kg/min and dobutamine 1.5-2 µg/kg/min during surgery. Intervention 2: The control group received 100 cc normal saline
Treatment - Drugs
Treatments in intervention group included trinitroglycerin 0.1 µg/kg/min and dobutamine 1.5-2 µg/kg/min during surgery
The control group received 100 cc normal saline as placebo during the surgery
Sponsors
Vice chancellor for research, Iran university of medical sciences
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: inclusion criteria : Patient's satisfaction with participating in the study; Patients with group I and II ASA Score; No history of Liver or Renal insufficiency, DM, HTN, Heart and Pulmonary disease; No acid-base disorders; No TNG, dubotamine or anesthetic drugs allergy; No emergent surgery; No pregnancy; No contraindications of TNG(Idiopathic hypertrophic subaortic stenosis, post myocardial infarction hypertension); No contraindications of dubotamine( myocardial infarction, open angle glaucoma, allergy to phosphodiesterase inhibitors, cerebral hemorrhage, ICP rise, severe anemia, orthostatic hypotention, sildenafil use in restrictive cardiomyopathy). Exclusion Criteria: Resistant drop in blood pressure with mean arterial pressure less than 60; Increasing blood pressure needing therapeutic interventions more than predicted in study method.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum bicarbonate concentration. Timepoint: Before start of anesthesia, per hour during surgery, at the end of surgery. Method of measurement: Arterial Blood Gas Analysis.;Serum base deficit. Timepoint: Before start of anesthesia, per hour during surgery, at the end of surgery. Method of measurement: Arterial Blood Gas Analysis. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed