Effect of acetazolamide on the prevention of cerebrospinal fluid leakage after spinal surgery

Assessment of acetazolamide efficacy in preventing CSF leak after dural repair post spinal surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201501178612N2

Enrollment

Registered

2015-06-10

Start date

2014-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dura damage. Cerebrospinal fluid leak from spinal puncture

Interventions

Intervention 1: Intervention: 1. Acetazolamide oral tablet

20 mg/kg/day in 3-4 daily doses for 7 days post surgery 2. Patient in position 3/4 lateral. Intervention 2: Control: 1. Patient in position 3/4 lateral.

Treatment - Drugs

Intervention: 1. Acetazolamide oral tablet

20 mg/kg/day in 3-4 daily doses for 7 days post surgery 2. Patient in position 3/4 lateral

Control: 1. Patient in position 3/4 lateral

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion: Dura tear during spinal surgery; Intra-dural tumor; trauma-related dura tear Exclusion: previous surgery and dura tear in the same location; history of chemotherapy or radiotherapy; malnutrition; uncontrolled metabolic disease

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
CSF leakage. Timepoint: Daily until 8 weeks post discharge. Method of measurement: observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactElham Amini PharmD

Shariati Hospital

elhamamini.pharm@gmail.com+98 21 8490 2272

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026