The comparison of the effect of magnesium oxide and sodium valproate in migraine prophilaxis:

The comparison of the effect of magnesium oxide and sodium valproate in migraine prophilaxis: A prospective double blind randomized clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015011716666N2

Enrollment

Registered

2015-03-05

Start date

2015-03-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Migrain headache. Migraine

Interventions

Intervention 1: Control group: Tab. Valproat Na 200mg BD for 2 month. Intervention 2: intervention: tab magnesium oxide 250 mg BD for 2 month.

Treatment - Drugs

Control group: Tab. Valproat Na 200mg BD for 2 month

intervention: tab magnesium oxide 250 mg BD for 2 month

Eligibility

Sex/Gender

All

Age

15 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: migraine headache on based criteria IHS; age between 15-65 years old; migraine headache from 6 month ago; headache frequency: more than twice a month with moderate or sever intensity; not used valproate Na and MG within the past 30 days. Exclusion criteria: pregnancy; breastfeeding; renal and hepatic failure; non migraine headache; smoking and opium and substance abuse.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Headache intensity. Timepoint: 2 months after used drug. Method of measurement: Questionnaire MIDAS and VAS 1-10.;Headache frequency. Timepoint: 2 months after used drug. Method of measurement: Questionnaire MIDAS.;Headache duration. Timepoint: 2 months after used drug. Method of measurement: Questionnaire MIDAS.	—

Secondary

Measure	Time frame
Headache symptom. Timepoint: 2 month after use drug. Method of measurement: Questionnair.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNarges karimi

Mazandaran University of Medical Sceinces

drkarimi_236@yahoo.com+98 11 3334 3018

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026