Diabetes mellitus type 2. Non insulin dependent diabetes mellitus
Conditions
Interventions
Intervention 1: In the beginning patients followed diet regimen alone for three months. Intervention 2: After 3 months of diet regimen alone, treatment with metformin with a minimum dose of 500 millig
Treatment - Drugs
In the beginning patients followed diet regimen alone for three months
After 3 months of diet regimen alone, treatment with metformin with a minimum dose of 500 milligrams daily to a maximum dose of 2500 milligrams per day in three divided doses by mouth, according to th
Sponsors
Vice-Chancellor for Research of Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age range of 30 to 75 years old; type 2 of diabetes mellitus; absent previous history of diabetic ketoacidosis; fasting blood sugar 135 milligrams per deciliter or more and 2 hours postprandial blood sugar 180 milligrams per deciliter or more. Exclusion criteria: consumption of vitamin B12, folic acid or drugs with effects on folate metabolism (such as: anticonvulsants, antirheumatologic, and antineoplastic medications); renal function defect (serum creatinine level greater than 1.3 milligram in deciliter) ; pregnancy or trying to become pregnant; history of surgery on gastrointestinal tract (stomach or ileum) ; history of hypothyroidism; class III or more of congestive heart failure presence of malignant disorders; presence of psychiatric diseases; treatment with antibiotics; uncontrolled blood sugar during the intervention
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum level of homocysteine. Timepoint: In the beginning and 3 to 6 months after starting the intervention. Method of measurement: Measurement of serum level of homocysteine by enzyme immunoassay method.;Serum level of folic acid. Timepoint: In the beginning and 3 to 6 months after starting the intervention. Method of measurement: Measurement of serum level of folic acid by radioimmunoassay method.;Serum level of vitamin B12. Timepoint: In the beginning and 3 to 6 months after starting the intervention. Method of measurement: Measurement of serum level of vitamin B12 by radioimmunoassay method. | — |
Secondary
| Measure | Time frame |
|---|---|
| Fasting blood sugar. Timepoint: In the beginning and then every 6 weeks. Method of measurement: Blood test by glucose dehydrogenase method.;Two hours postprandial blood sugar. Timepoint: In the beginning and then every 6 weeks. Method of measurement: Blood test by glucose dehydrogenase method.;Lipid profile. Timepoint: In the beginning and then 3 and 6 months after starting the study. Method of measurement: Blood test by cholesterol oxidase/ peroxidase and glycerol phosphate oxidase/ peroxidase and direct enzymatic methods.;Glycated hemoglobin (HbA1c) level. Timepoint: In the beginning and 3 to 6 months after starting the study. Method of measurement: Direct enzymatic assay.;Weight of the patients. Timepoint: In the beginning and 3 and 6 months after starting the study. Method of measurement: By standard stadiometer.;Body mass index. Timepoint: In the beginning and 3 and 6 months after starting the study. Method of measurement: By the formula: weight in kilograms divided by height in meters squared. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDoctor Fariba Karimi
Shiraz University of Medical Sciences
Outcome results
None listed