Methadone Overdose. Poisoning by Methadone
Conditions
Interventions
Intervention 1: Narcan Injection (case group). Intervention 2: Buprenorphine (5micro/kg
1st Control Group). Intervention 3: Buprenorphine (10micro/kg
2nd Control group).
Treatment - Drugs
Narcan Injection (case group)
Buprenorphine (5micro/kg
1st Control Group)
Buprenorphine (10micro/kg
2nd Control group)
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
12 Years to 100 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: all opioid-dependant patients who refer after methadone overdose will be included and randomly assigned into either case (buprenorphine with two different doses) or control (naloxone) group. Exclusion criteria: 1-Those younger than 12 years of age and older than 100 years will be excluded. 2- Patients with multiple drug overdoses will be excluded. 3-Patients who do not respond to the buprenorphien and naloxone doses and are in life-treathening situation will be intubated and excluded from the study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reversal of Respiratory Depression. Timepoint: 1 min. Method of measurement: reversal of respiratory rate. | — |
Secondary
| Measure | Time frame |
|---|---|
| Reversal of cyanosis and increased O2 Saturation. Timepoint: 2 minutes. Method of measurement: Pulse Oximetry. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Nasim Zamani
Shahid Beheshti University of Medical Sciences
Outcome results
None listed