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Comparison of the effects of Ketamine-Metoclopramide and Acetaminophen-Metoclopramide in deep Vitrectomy surgery

Comparison of the effect of Ketamine-Metoclopramide and Acetaminophen-Metoclopramide combination administration on pain intensity after deep Vitrectomy surgery

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20150106020588N9
Enrollment
68
Registered
2022-09-11
Start date
2016-10-22
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vitrectomy. Disorders of vitreous body

Interventions

Intervention 1: Intervention group A: The patients in this group received 5 mg/kg of Ringer lactate solution for each kilogram of body weight, using 5 mg/kg sodium Thiopental manufactured by Exir Comp

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 80 Years

Inclusion criteria

Inclusion criteria: Candidate for Vitrectomy surgery Age 40 to 80 years ASA class I and II Informed consent to enter the study

Exclusion criteria

Exclusion criteria: History for abusing the drugs, alcohol and psychedelics Known allergy to ketamine, Acetaminophen, and Metoclopramide History of mental illness and seizures Pregnancy and breastfeeding Body Mass Index (BMI) greater than 35 Taking painkillers 24 hours before surgery

Design outcomes

Primary

MeasureTime frame
The amount of pain after the operation. Timepoint: Upon entering recovery, 30 minutes, 2 hours, 4 hours, 8 hours, 24 hours after surgery. Method of measurement: Visual Analogue Scale.

Secondary

MeasureTime frame
Heart Rate. Timepoint: Upon entering recovery, 30 minutes, 2 hours, 4 hours, 8 hours, 24 hours after surgery. Method of measurement: Electrocardiogram.;Blood Pressure. Timepoint: Upon entering recovery, 30 minutes, 2 hours, 4 hours, 8 hours, 24 hours after surgery. Method of measurement: Sphygmomanometer.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDariush Moradi Farsani

Esfahan University of Medical Sciences

dmoradi@med.mui.ac.ir+98 31 3668 8597

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026