Comparison of the effects of Atropine and Tetracaine on Oculo Cardiac Reflex (OCR) in strabismus surgery

Comparison of the effectiveness of preoperative administration of intravenous Atropine and topical Tetracaine on the incidence and severity of Oculo Cardiac Reflex (OCR) in strabismus surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150106020588N8

Enrollment

120

Registered

2022-08-13

Start date

2018-04-21

Completion date

Unknown

Last updated

2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Strabismus. Other strabismus

Interventions

Intervention 1: Intervention group 1: Patients in this group after inducting of anesthesia using 5 mg/kg of Thiopental sodium manufactured by Elixir Company, an amount of 0.5 mg/kg of Atracurium manuf

Eligibility

Sex/Gender

All

Age

10 Years to 70 Years

Inclusion criteria

Inclusion criteria: Candidate for Strabismus surgery Age 10 to 70 years ASA class I and II informed consent to enter the study

Exclusion criteria

Exclusion criteria: Allergic to Atropine, Tetracaine and artificial tears Cardiovascular diseases history

Design outcomes

Primary

Measure	Time frame
Heart Rate. Timepoint: Before induction, immediately after the induction of anesthesia and then every 5 minutes to 30 minutes, and then every 10 minutes until the end of the surgery. Method of measurement: ECG monitoring.;Blood Pressure. Timepoint: Before induction, immediately after the induction of anesthesia and then every 5 minutes to 30 minutes, and then every 10 minutes until the end of the surgery. Method of measurement: Sphygmomanometer.	—

Measure

Time frame

Heart Rate. Timepoint: Before induction, immediately after the induction of anesthesia and then every 5 minutes to 30 minutes, and then every 10 minutes until the end of the surgery. Method of measurement: ECG monitoring.;Blood Pressure. Timepoint: Before induction, immediately after the induction of anesthesia and then every 5 minutes to 30 minutes, and then every 10 minutes until the end of the surgery. Method of measurement: Sphygmomanometer.

—

Secondary

Measure	Time frame
Surgery Duration. Timepoint: From the moment of surgical intervention to the end of eye dressing. Method of measurement: Timer.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDariush Moradi Farsani

Esfahan University of Medical Sciences

dmoradi@med.mui.ac.ir+98 31 3668 8597

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026