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Effect of selenium on oral inflammation

Effect of selenium on prevention or alleviation of oral mucositis induced by radiotherapy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2015010511192N4
Enrollment
30
Registered
2015-03-15
Start date
2015-04-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mucositis. K12.3

Interventions

Intervention 1: Group selenium: Adminstration of selenium 400 mcg/day orally just before starting radiotherapy and continuing for 5 weeks. Intervention 2: Group placebo: Adminstration of placebo oral
Treatment - Drugs
Group selenium: Adminstration of selenium 400 mcg/day orally just before starting radiotherapy and continuing for 5 weeks
Group placebo: Adminstration of placebo orally just before starting radiotherapy and continuing for 5 weeks

Sponsors

Depeuty of Research, Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients with diagnosis of oral;nasopharynx or hypopharynx cancer; who recieve at least 5000 centi gray radiation; at lest 2 locations of oral suitable fior radiotherapy Exclusion criteria: Patients under 18 years old

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Mucosistis severity. Timepoint: Bbaseline;first week;second week;Third week;Fourth week; Fifth week. Method of measurement: Clinical examination.

Secondary

MeasureTime frame
Drug hypersensitivity;Headache. Timepoint: Weekly. Method of measurement: Question from patient.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Abbasinazari

School of pharmacy, Shahid Beheshti University of Medical Sciences

m_abbasi@sbmu.ac.irFarshadpharm@yahoo.com+98 21 8887 3704

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026