Comparison the effect of granulocyte colony stimulating factor (G-CSF) on the success rate of frozen embryo transfer cycle

Comparison of the effect of granulocyte colony-stimulating factor (G-CSF) injection in the sub endometrium on the success rate of frozen embryo transfer cycle in women with repeated implantation failure

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150105020558N7

Enrollment

100

Registered

2024-05-31

Start date

2024-07-22

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female infertility. Female infertility

Interventions

Intervention 1: Intervention group: In the luteal phase of the cycle before embryo transferring, hysteroscopy is performed. During hysteroscopy, 300 micrograms of G-CSF is injected into four sub-endom

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: infertile women with repeated implantation failure with good quality embryo (Grade A or B)

Exclusion criteria

Exclusion criteria: Patients with husband having azoospermia Patients with uterine malformations, endometrial polyps, submucosal fibroids, or intrauterine adhesions History of surgery on the uterus due to acquired or congenital uterine abnormalities Patients with severe endometriosis (stage 3, 4)

Design outcomes

Primary

Measure	Time frame
Live birth. Timepoint: Once, after pregnancy termination. Method of measurement: Questioning.;Ongoing pregnancy. Timepoint: Once, after the 20th week of pregnancy. Method of measurement: Ultrasound of the fetus.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahbod Ebrahimi

Tehran University of Medical Sciences

maebrahimi@tums.ac.ir+98 21 8882 7794

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026