Investigating the effect of increasing the amount of prescribed progesterone on the pregnancy success rate

Investigating the effect of daily intramuscular injection of 50 mg progesterone and 800 mg progesterone suppository on the pregnancy success rate in women with low progesterone levels

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150105020558N6

Enrollment

218

Registered

2023-02-28

Start date

2023-04-09

Completion date

Unknown

Last updated

2023-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female infertility. Female infertility

Interventions

Intervention 1: Intervention group: From the day of embryo transfer, 50 mg ampoule progesterone (intramuscular injection) is prescribed once a day in addition to 400 mg progesterone suppositories eve

Eligibility

Sex/Gender

Female

Age

18 Years to 38 Years

Inclusion criteria

Inclusion criteria: Women with a three-layered endometrial pattern with sufficient thickness (7 mm) after receiving estrogen Progesterone level less than 9.2 ng/ml on the day of transfer With at least two three-day frozen embryos of good quality (AA, AB, BB)

Exclusion criteria

Exclusion criteria: The presence of underlying diseases such as malignancy, advanced heart failure, cirrhosis, progressive chronic neurological diseases, and uterine disorders such as fibroids, polyps, or hydrosalpinx.

Design outcomes

Primary

Measure	Time frame
Live birth. Timepoint: Once, after pregnancy termination. Method of measurement: The number of deliveries that resulted in a live-born neonate.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahbod Ebrahimi

Tehran University of Medical Sciences

maeb214@yahoo.com+98 21 4216 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 5, 2026