Letrozole effect in IVF cycles

Comparison of the Effectiveness of Letrozole with Estradiol on Frozen Embryo Transfer Cycle Outcomes in Women with Polycystic Ovarian Syndrome

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150105020558N3

Enrollment

510

Registered

2021-03-02

Start date

2021-04-21

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovarian syndrome. Polycystic ovarian syndrome

Interventions

Intervention 1: Intervention group: In this group, two letrozole tablets (2.5 mg, ?Aburaihan pharmaceutical co) is prescribed orally for 5 days initiating on day 3 of spontaneous menses or progesteron

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: The patients with impression of polycystic ovarian syndrome according to Rotterdam consensus as fulfilling at least two of the three criteria: 1- oligo/anovulation; 2- clinical or biochemical signs of hyperandrogenism; and 3- polycystic ovarian morphology on ultrasound Female age: 18 - 40 years old The candidate of frozen embryo transfer

Exclusion criteria

Exclusion criteria: The other causes of hyperandrogenism and ovarian dysfunction Basal FSH level >10 IU/L History of recurrent miscarriage History of congenital or acquired uterine malformations History of male factor infertility

Design outcomes

Primary

Measure	Time frame
Live Birth Rate. Timepoint: After pregnancy termination. Method of measurement: The number of deliveries that resulted in a live born neonate, expressed per 100 embryo transfers.	—

Secondary

Measure	Time frame
Clinical Pregnancy Rate. Timepoint: 4 to 6 weeks after frozen embryo transfer. Method of measurement: A visible gestational sac by transvaginal ultrasound.;Ongoing Pregnancy Rate. Timepoint: After 20th weeks of pregnancy. Method of measurement: The number of fetuses with heart activity beyond 20 weeks of gestation.;Cycle cancellation rate. Timepoint: from 15th until 21th days of cycle. Method of measurement: The number of cancelled cycles.;Endometrial thickness. Timepoint: On the day of HCG injection. Method of measurement: The measuring of endometrial thickness by transvaginal ultrasound.;Abortion rate. Timepoint: From 5th until 24th gestational weeks. Method of measurement: The detection of lack or loss of fetal heart activity by ultrasound.;Premature delivery rate. Timepoint: From 25th until 36th gestational weeks. Method of measurement: The delivery of fetus(es).	—

Measure

Time frame

Clinical Pregnancy Rate. Timepoint: 4 to 6 weeks after frozen embryo transfer. Method of measurement: A visible gestational sac by transvaginal ultrasound.;Ongoing Pregnancy Rate. Timepoint: After 20th weeks of pregnancy. Method of measurement: The number of fetuses with heart activity beyond 20 weeks of gestation.;Cycle cancellation rate. Timepoint: from 15th until 21th days of cycle. Method of measurement: The number of cancelled cycles.;Endometrial thickness. Timepoint: On the day of HCG injection. Method of measurement: The measuring of endometrial thickness by transvaginal ultrasound.;Abortion rate. Timepoint: From 5th until 24th gestational weeks. Method of measurement: The detection of lack or loss of fetal heart activity by ultrasound.;Premature delivery rate. Timepoint: From 25th until 36th gestational weeks. Method of measurement: The delivery of fetus(es).

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahbod Ebrahimi

Tehran University of Medical Sciences

maeb214@yahoo.com+98 21 4216 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026