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Effect granulocyte colony stimulation factor (GCSF) versus placebo on implantation among infertile patients who underwent assisted reproductive technology (ART)

Effect granulocyte colony stimulation factor (GCSF) versus placebo on implantation among infertile patients who underwent assisted reproductive technology (ART): a randomzed clinical trial

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT201501049014N52
Enrollment
30
Registered
2015-01-07
Start date
2013-11-22
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility

Interventions

Intervention 1: transvaginal injection of GCSF 300 IU, single dose, 2 or 5 days before embryo transfer. Intervention 2: prescription of OCP for 21 days plus 50 mcg GNRH agonist single dose on the 3rd
Treatment - Drugs
Placebo
transvaginal injection of GCSF 300 IU, single dose, 2 or 5 days before embryo transfer.
prescription of OCP for 21 days plus 50 mcg GNRH agonist single dose on the 3rd day of menstrual period and 300 to 450 IU FSH or HMG, single dose, on the 14th day of menstrual period.

Sponsors

Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: (a) Infertile; (b) age of 20 to 40 years; (c) having determined factor such as endometriosis, myoma, or Asherman's syndrome. Exclusion criteria: (a) having cycle cell anemia, renal failure, upper or lower respiratory infection, or malignancy; (b) contraindication for pregnancy; (c) weak response rate.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Diagnosis of gestational sac and observation of embryo. Timepoint: 24 days after embryo transfer. Method of measurement: by transvaginal ultrasonography.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Zahra yazdi

Fatemieh Hospital

zyazdi88@yahoo.com+98 81 3827 7459

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026