Major Depressive episode. Depressive episode
Conditions
Interventions
Intervention 1: Cap citalopram 40 mg/day as control group for 6 weeks. Intervention 2: Capsule saffron 30mg/day as intervention group for 6 weeks.
Treatment - Drugs
Cap citalopram 40 mg/day as control group for 6 weeks
Capsule saffron 30mg/day as intervention group for 6 weeks
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1-Presence of Major Depressive Disorder, with anxious distress based on DSM-5 criteria; 2- age between 18 to 65 years old; 3-score lower than 20 in Hamilton Rating Scale for depression. Exclusion criteria: 1-Psychotic symptoms; 2-receiving another psychotropic medications; 3-receiving any antidepressants during past one month or ECT during past two months; 4-Presence of hypothyroidism; 5-nursing and pregnant women; 6-srious suicidality during the last year; 7-women who want to be pregnant during the future months; 8-women who are receiving OCP; 9-receiveng aspirin and anticoagulants and NSAIDs.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of anxiety. Timepoint: Baseline and weeks: 2, 4 and 6 after beginig of treatment. Method of measurement: By Hamiltion Anxiety Rating Scale.;Severity of depression. Timepoint: Baseline and weeks: 2, 4 and 6 after beginig of treatment. Method of measurement: By HamiltionDepression Rating Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactProf. Shahin Akhondzadeh
Tehran University of Medical Sciences
Outcome results
None listed