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Effects of Topiramate Tablets in Prophylaxis of Febrile Convulsion

Comparison of Oral Topiramate and Diazepam in Prophylaxis of Febrile Convulsion in Case of Children under Two Years with Limitation in Phenobarbital Prescription

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2015010120527N1
Enrollment
32
Registered
2015-11-22
Start date
2013-12-08
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Febrile convulsions. Febrile Convulsions

Interventions

Intervention 1: For treatment group, oral Topiramat at 9 mg/kg of body weight taken daily in two turns was administered. The administration of drug was continued for one year if Febrile Convulsion has
Treatment - Drugs
For control group, only in the first three days of fever, oral Diazepam at 1mg/kg of body weight taken daily in three turns was administered. The administration of drug was continued for one year if F
For treatment group, oral Topiramat at 9 mg/kg of body weight taken daily in two turns was administered. The administration of drug was continued for one year if Febrile Convulsion has not recurred.

Sponsors

Vice chancellor for research, Hamadan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Months to 2 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Children aged between 1 and 24 months; Meeting the conditions of prophylaxis for Febrile Convulsion; The impossibility of using Phenobarbital Exclusion criteria: Change in initial diagnosis

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Febrile Convulsion. Timepoint: Every two months after intervention. Method of measurement: Questionnaire.

Secondary

MeasureTime frame
Urinary tract stones,. Timepoint: End of plan. Method of measurement: Ultrasound.;Fever. Timepoint: Every two months after intervention. Method of measurement: Thermometer.;Weight. Timepoint: Before intervention and every two months after intervention. Method of measurement: Scale.;Cough. Timepoint: Every two months after intervention. Method of measurement: Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Afshin Fayyazi

Hamadan University of Medical Sciences

Afshin_fay@yahoo.com, Afshinfay@yahoo.com+98 81 3838 1491

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026