Mesenchymal exosome extract for boosting skin microneeding procedure

Investigating the safety and effectiveness of exosomes derived from mesenchymal stem cells in skin regeneration after microneedling procedure

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150101020514N36

Enrollment

Registered

2025-09-06

Start date

2025-08-23

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

skin aging. Changes in skin texture

Interventions

Intervention 1: Intervention group: Half of the patient’s face is considered as the intervention group. In this group, the right half of the patient’s face is treated with a sterile exosome cocktail d

Eligibility

Sex/Gender

All

Age

30 Years to 60 Years

Inclusion criteria

Inclusion criteria: Men & women aged 30-60 years Possibility to accompany the visit plans and study process. Signing an informed consent form and agreed to follow up.

Exclusion criteria

Exclusion criteria: Malignancy Chemotherapy in less that 5 years Sepsis Smoking Pregnancy or breast feeding Wound or infection at the face skin Consuming any therapeutics for chronic skin condition Any discontinuation of the process related to the patient unsatisfaction or etc.

Design outcomes

Primary

Measure	Time frame
Improvement of skin rejuvenation and radiance. Timepoint: 7 days, 14 days and 28 days after procedure. Method of measurement: Participants will be selected according to the inclusion and exclusion criteria. After describing the clinical trial procedure for participants, a consent form is obtained from them. Digital images, full face and side view images will be taken by a professional operators. Biophysical skin parameters will be assessed, including: Stratum corneum hydration.Transepidermal water loss (TEWL)Skin pigmentation indices (melanin and erythema)Skin elasticity parameters (R0, R2, and R5) Ultrasonographic parameters of the skin (dermal thickness and density)These measurements will be conducted on both the right and left cheek regions. The study will be carried out at the Center for Research & Teaching Skin Diseases & Leprosy.;Reduction of inflammation after micro-needling procedure. Timepoint: 2h after microneedling procedure. Method of measurement: Inflammation is assessed based on clinical examination by the treating physician as well as through the Visioface device.	—

Measure

Time frame

Improvement of skin rejuvenation and radiance. Timepoint: 7 days, 14 days and 28 days after procedure. Method of measurement: Participants will be selected according to the inclusion and exclusion criteria. After describing the clinical trial procedure for participants, a consent form is obtained from them. Digital images, full face and side view images will be taken by a professional operators. Biophysical skin parameters will be assessed, including: Stratum corneum hydration.Transepidermal water loss (TEWL)Skin pigmentation indices (melanin and erythema)Skin elasticity parameters (R0, R2, and R5) Ultrasonographic parameters of the skin (dermal thickness and density)These measurements will be conducted on both the right and left cheek regions. The study will be carried out at the Center for Research & Teaching Skin Diseases & Leprosy.;Reduction of inflammation after micro-needling procedure. Timepoint: 2h after microneedling procedure. Method of measurement: Inflammation is assessed based on clinical examination by the treating physician as well as through the Visioface device.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactForouhe Zahir

Tehran University of Medical Sciences

Forouhezahirjouzdani@gmail.com+98 21 8897 7921

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026