Safety and efficacy comparison of gel and emulgel formulations of Tertinoin and Clindamaycin for treatment of mild to moderate acne vulgaris

Safety and efficacy comparison of gel and emulgel formulations of tretinoin 0.025% and clindamaycin 1.2% for treatment of mild to moderate acne vulgaris

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150101020514N13

Enrollment

Registered

2021-12-13

Start date

2021-12-22

Completion date

Unknown

Last updated

2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne vulgaris. Acne vulgaris

Interventions

Intervention 1: Intervention group: Topical application of compounding emulgel (not industrial) containing tretinoin 0.025% and clindamaycin 1.2% on acne lesions of one side of the face (randomly) onc

Eligibility

Sex/Gender

All

Age

16 Years to 40 Years

Inclusion criteria

Inclusion criteria: Male or female aged 16-40 years Mild to moderate inflammatory or non-inflammatory acne lesions (grade 1 to 3 according to the table) on face

Exclusion criteria

Exclusion criteria: People with allergies to formulation ingredients Nodular or cystic lesions that represent a severe type of acne vulgaris

Design outcomes

Primary

Measure	Time frame
Evaluate the improvement of acne severity index by a physician. Timepoint: Before intervention, 4 and 8 weeks after the start of use. Method of measurement: An independent dermatologists perform evaluation and scoring with the help of photos based on the percentage of improvement in acne using:(0=normal skin, 2=skin is almost clear, 3=some non-inflammatory lesions are present, 4=non-inflammatory lesions are predominant, with multiple inflammatory lesions. 5=highly inflammatory lesions predominate).	—

Measure

Time frame

Evaluate the improvement of acne severity index by a physician. Timepoint: Before intervention, 4 and 8 weeks after the start of use. Method of measurement: An independent dermatologists perform evaluation and scoring with the help of photos based on the percentage of improvement in acne using:(0=normal skin, 2=skin is almost clear, 3=some non-inflammatory lesions are present, 4=non-inflammatory lesions are predominant, with multiple inflammatory lesions. 5=highly inflammatory lesions predominate).

—

Secondary

Measure	Time frame
Trans Epidermal Water Loss. Timepoint: Before intervention, 4 and 8 weeks after the start of use. Method of measurement: Tewameter.;Skin sebum. Timepoint: Before intervention, 4 and 8 weeks after the start of use. Method of measurement: Sebumeter.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAniseh Samadi

Tehran University of Medical Sciences

aniseh_samadi@yahoo.com+98 21 8896 0880

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026