Venous embolism and thrombosis. Other venous embolism and thrombosis
Conditions
Interventions
Intervention 1: Intervention group: In the intervention group, 12 hours before surgery, 0.5 mg/kg enoxaparin (Iranhormone, Iran) will be injected subcutaneously, then 2.5 mg apixaban (Exir, Iran) will
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 89 Years
Inclusion criteria
Inclusion criteria: Patients diagnosed with gynecological cancers (ovarian, uterine, cervical, or vulvar) undergo laparotomy surgery.
Exclusion criteria
Exclusion criteria: Long-term use of non-steroidal anti-inflammatory drugs Patients with coagulation or bleeding disorders, severe kidney or liver diseases, valvular heart diseases Using thrombogenic drugs, selective serotonin reuptake inhibitors, or serotonin-norepinephrine reuptake inhibitors History of venous thromboembolism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Major bleeding incidence. Timepoint: Once, 30 days after the surgery. Method of measurement: Questioning.;Non-major bleeding incidence with clinical significance (requiring intervention). Timepoint: Once, 30 days after the surgery. Method of measurement: Questioning. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactArezoo Esmailzadeh
Tehran University of Medical Sciences
Outcome results
None listed