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Comparison of the effect of tranexamic acid and dexmedetomidine on amount of bleeding in cosmetic nose surgery

Comparison of the effect of tranexamic acid and dexmedetomidine on intra-operative bleeding in patients candidate for rhinoplasty

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT2014122520434N1
Enrollment
76
Registered
2015-07-16
Start date
2015-09-23
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rhinoplasty. Other reconstructive surgery

Interventions

Intervention 1: Intervention group 1: Tranexamic acid, 10 mg/kg, immediately after anesthesia induction, intravenously. Intervention 2: Intervention group 2: Dexmedetomidine, 1 µg/kg, immediately afte
Prevention
Intervention group 1: Tranexamic acid, 10 mg/kg, immediately after anesthesia induction, intravenously.
Intervention group 2: Dexmedetomidine, 1 µg/kg, immediately after anesthesia induction, intravenously.

Sponsors

Iran University of Medical Sciences, Vice Chancellor for Research
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patient satisfaction; Age between 18-60 years old; ASA class I-II. Exclusion criteria: Patients with liver, kidney, and cardiovascular diseases or diabetes mellitus; Opium addiction; Using benzodiazepines or clonidine; Sensitivity to study drugs; Pregnancy.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Surgeon satisfaction. Timepoint: From the onset of surgery to its end. Method of measurement: Based on surgeon opinion as good, moderate, and bad.;Bleeding volume. Timepoint: From the onset of surgery to its end. Method of measurement: The number of used gases.;Blood pressure. Timepoint: From the onset of surgery since 180 minutes later, every 30 minutes. Method of measurement: Sphygmometer.

Secondary

MeasureTime frame
Surgery duration. Timepoint: From the onset of surgery to its end. Method of measurement: Minute.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSamira

Berenjian

S_samira1357@yahoo.com+98 21 6435 2326

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026