Effects of flaxseed oil on hematologic factors, serum concentrations of hepcidin and cardiovascular risk factors in hemodialysis patients

Effects of flaxseed oil on hematologic factors, serum concentrations of hepcidin, bone markers and cardiovascular risk factors in hemodialysis patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201412192716N3

Enrollment

Registered

2015-01-02

Start date

2014-12-25

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Disease (Hemodialysis).

Interventions

Intervention 1: Intervention: Flaxseed oil containing omega-3 fatty acids (6 gr/day as one tablespoon for 8 weeks). Intervention 2: Control: MCT oil containing short and medium chain fatty acids (6 g

Treatment - Other

Placebo

Intervention: Flaxseed oil containing omega-3 fatty acids (6 gr/day as one tablespoon for 8 weeks)

Control: MCT oil containing short and medium chain fatty acids (6 gr/day as one tablespoon for 8 weeks)

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criterion: being on hemodialysis at least 6 months. Exclusion criteria: infections; inflammatory diseases; receiving anti-inflammatory drugs.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Systemic inflammation markers (hs-CRP, bone turnover markers). Timepoint: Baseline & week 8. Method of measurement: ELISA.	—

Secondary

Measure	Time frame
Hematologic factors (Hb, HCT, RBC, MCV, MCH, MCHC). Timepoint: Baseline, week 8. Method of measurement: Cell counter.;Hepcidin. Timepoint: Baseline, week 8. Method of measurement: ELISA.;Vascular inflammation markers (ICAM-1, VCAM-1, E-selectin). Timepoint: Baseline, week 8. Method of measurement: ELISA.;Oxidative stress (MDA). Timepoint: Baseline, week 8. Method of measurement: Colorimetery.;Lipid profile (TG,TC,LDL-C,HDL-C, Lp(a)). Timepoint: Baseline, week 8. Method of measurement: Lp(a) by ELISA; TG,TC,HDL-C by colorimetry; LDL-C by Frieldwald formula.	—

Measure

Time frame

Hematologic factors (Hb, HCT, RBC, MCV, MCH, MCHC). Timepoint: Baseline, week 8. Method of measurement: Cell counter.;Hepcidin. Timepoint: Baseline, week 8. Method of measurement: ELISA.;Vascular inflammation markers (ICAM-1, VCAM-1, E-selectin). Timepoint: Baseline, week 8. Method of measurement: ELISA.;Oxidative stress (MDA). Timepoint: Baseline, week 8. Method of measurement: Colorimetery.;Lipid profile (TG,TC,LDL-C,HDL-C, Lp(a)). Timepoint: Baseline, week 8. Method of measurement: Lp(a) by ELISA; TG,TC,HDL-C by colorimetry; LDL-C by Frieldwald formula.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Hadi Tabibi

Department of Human Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition

hadtabibi@yahoo.com+98 21 2207 7424

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026