The effect of ischemic postconditioning on myocardial protection

Studying the effect of ischemic postconditioning and controlled aortic root reperfusion on myocardial protection in CABG surgery with cardiopulmonary bypass

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014121520324N1

Enrollment

Registered

2015-02-07

Start date

2014-12-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular disease. Cardiovascular disease, unspecified

Interventions

Intervention 1: In second group three repetitive episodes of 1 min ischemia separated by 1 min of reperfusion (at systemic pressure) will be applied on coronary artery Then the clamp will be released

Prevention

In second group three repetitive episodes of 1 min ischemia separated by 1 min of reperfusion (at systemic pressure) will be applied on coronary artery Then the clamp will be released completely.

In third group, controlled perfusion pressure and post conditioning will be applied together during reperfusion of coronary artery.

All patients will undergo CABG operation with CPB assisted protocol, which will be conducted using a membrane oxygenator. Non pulsatile pump blood flow will be set at 2.4 times of body surface area an

Eligibility

Sex/Gender

All

Age

50 Years to 70 Years

Inclusion criteria

Inclusion criteria: inclusion criteria: Age 50-70 years old; Ejection fraction more than 40 percent; Complete occlusion of LAD; No redo cardiac operation Excluction criteria: concomitant operation; aortic clamp time more than 100 minute; CPB time more than 130 minute

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Ejection Fraction. Timepoint: Before and 7 days after operation. Method of measurement: Echocardiography.;Cardiac dysrhythmia. Timepoint: After operation for 72 hours. Method of measurement: Cardiac monitoring and Electrocardiography.;Oxidative stress enzymes. Timepoint: before starting of operation, Before starting coronary reperfusion, ten minute after reperfusion, 1st, 2nd, and 3rd days after operation. Method of measurement: Blood analyses.;Cardiac Enzymes. Timepoint: Before starting the operation, before starting coronary reperfusion, ten minute after reperfusion, 1st, 2nd, and 3rd days after operation. Method of measurement: biochemical analyses of blood.	—

Measure

Time frame

Ejection Fraction. Timepoint: Before and 7 days after operation. Method of measurement: Echocardiography.;Cardiac dysrhythmia. Timepoint: After operation for 72 hours. Method of measurement: Cardiac monitoring and Electrocardiography.;Oxidative stress enzymes. Timepoint: before starting of operation, Before starting coronary reperfusion, ten minute after reperfusion, 1st, 2nd, and 3rd days after operation. Method of measurement: Blood analyses.;Cardiac Enzymes. Timepoint: Before starting the operation, before starting coronary reperfusion, ten minute after reperfusion, 1st, 2nd, and 3rd days after operation. Method of measurement: biochemical analyses of blood.

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Secondary

Measure	Time frame
-. Timepoint: -. Method of measurement: -.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Ali Sheikhalizadeh

Tabriz University of Medical Sciences

seikhali@yahoo.com+98 41 3336 0894

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026