The effect of topical injection of tramadol, ketamine and lidocaine on post-tonsillectomy pain, nausea and vomiting

Comparison of the effect of topical injection of tramadol, ketamine and lidocaine on post-tonsillectomy pain, nausea and vomiting

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014121520320N1

Enrollment

Registered

2015-04-10

Start date

2015-01-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic tonsillitis? tonsils and adenoids hypertrophy. Chronic diseases of tonsils and adenoids

Interventions

Intervention 1: Intervention group 1: Ketamin 0.5 mg/kg 2cc total, 1cc injection before operation in each tonsillar bed. Intervention 2: Intervention group 2: tramadol 2 mg/kg Daroupakhsh, Iran 2cc

Treatment - Drugs

Placebo

Intervention group 1: Ketamin 0.5 mg/kg 2cc total, 1cc injection before operation in each tonsillar bed

Intervention group 2: tramadol 2 mg/kg Daroupakhsh, Iran 2cc total, 1cc injection before operation in each tonsillar bed

Intervention group 3: lidicaine hydrochloride 20 mg/ml +epinephrine 0.00125% 2cc total, 1cc injection before operation in each tonsillar bed

Control goup: saline 2 cc, 1cc in each tonsilar bed

Eligibility

Sex/Gender

All

Age

4 Years to 15 Years

Inclusion criteria

Inclusion criteria: inclusion criteria: patient with chronic tonsillitis exclusion criteria: patients with any underlying disease, with drug reaction history, and whom the surgery time is more than one hour

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: 1,4,8,16,24 hour post-operation. Method of measurement: faces pain scale.;Nausea. Timepoint: 1,4,8,16,24 hour post-operation. Method of measurement: 4 option scale: none,mild, moderate, sever.;Vomiting. Timepoint: 1,4,8,16,24 hour post-operation. Method of measurement: none,mild(1 episode),moderate(2-3), severe(>3 episode).	—

Secondary

Measure	Time frame
Surgery time. Timepoint: start and finish time of surgery. Method of measurement: minutes.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Somaye Araghi

Jondishapour Ahvaz University of Medical Sciences

savesina@yahoo.com+98 61 3333 9664

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026