Termination of pregnancy in the first trimester. Termination of pregnancy, fetus and newborn
Conditions
Interventions
Intervention 1: Intervention Group:
In the Intervention group treatment is being performed on an out-patient basis for 2 days with Letrozole (made by Iran Hormone Co.) as 7.5 mg orally once a day, a
Treatment - Drugs
Placebo
Intervention Group:
In the Intervention group treatment is being performed on an out-patient basis for 2 days with Letrozole (made by Iran Hormone Co.) as 7.5 mg orally once a day, and on the third
Control Group:
In the control group treatment is being performed by placebo (folic acid as single blind – made by Iran Daru Co.) for 2 days and on the third day 800 mcg vaginal Misoprostol is being
Sponsors
Vice Chancellor for Research and Technology, Babol University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Following 12 weeks of pregnancy; Reason for termination of pregnancy, such as missed abortion; Pregnancy NULL; Therapeutic abortion legal authorization and consent of patients Exclusion criteria: Pain and bleeding; Drug sensitivity to misoprostol; Severe anemia; Coagulopathy or taking anticoagulants; Active liver disease; Cardiovascular disease and uncontrolled seizures; Adrenal disease, or a history of corticosteroid use
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Abortion. Timepoint: The start of the intervention up to 24. Method of measurement: Ultrasound.;Time between medication abortion. Timepoint: The start of the intervention up to 24. Method of measurement: Ultrasound.;The need for curettage. Timepoint: Seven days after abortion. Method of measurement: Clinical. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: Intervention to 24 hours after administration. Method of measurement: Clinical. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Zeinab Azmoodeh Fard
Babol University of Medical Sciences
Outcome results
None listed