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Comparison of the effect of letrozole /Estradiol and Misoprostol in labor induction

The effect of misoprostol / ?estradiol compared with ?misoprostol in labor ?induction ?

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT2014120920264N1
Enrollment
200
Registered
2017-10-29
Start date
2015-04-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

labor. Death from direct obstetric cause

Interventions

Intervention 1: Intervention group:In this group, 25 microgram of Misoprostol vaginal cervix to start preparing favorable with 50 Micrograms of Estradiol (two pills Vagifom witch each pill contains 2
Treatment - Drugs
Intervention group:In this group, 25 microgram of Misoprostol vaginal cervix to start preparing favorable with 50 Micrograms of Estradiol (two pills Vagifom witch each pill contains 25 micrograms of
Control group: In this group to begin to prepare a favorable cervix, vaginal 25 micrograms of Misoprostol will be used.

Sponsors

Vice chancellor for research, Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
15 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Gestational age over 36 weeks; singleton pregnancy with a vertex presentation; the absence of contraindications to vaginal delivery Exclusion criteria: Indication for emergency childbirth; History of liver and kidney disease; History of fetal distributors; History of contraindications use misoprostol (such as the mother's risk of blood coagulation disorders, asthma, glaucoma, etc).

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Cervical ripening. Timepoint: The Bishop score less than 4 until the Bishop score of above 7. Method of measurement: vaginal exam.

Secondary

MeasureTime frame
Duration of delivery. Timepoint: Every 4 hours. Method of measurement: vaginal exam.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyedeh Azam Pourhoseini

Mashhad University of Medical Sciences

pourhoseinia@mums.ac.ir+98 51 3802 2608

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026