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Comparison oral caffeine and oral Melatonin on prevention of headache caused by spinal anesthesia in lower limb surgery

Comparison between oral caffeine and oral Melatonin on prevention of headache caused by spinal anesthesia in lower limb surgery

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20141209020258N94
Enrollment
150
Registered
2019-01-10
Start date
2018-07-23
Completion date
Unknown
Last updated
2019-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Headache caused by spinal anesthesia. Other complications of anaesthesia

Interventions

Intervention 1: Intervention group: We treat 1 capsule containing 300 mg of caffeine(Super natural Canada) in caffeine group. Intervention 2: Intervention group: We treat 3 milligram Melatonin(natrol

Sponsors

Vice chancellor for research,Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: More than 18 years No allergy to caffeine and Melatonin No history of chronic migraine headaches, hypertension, diabetes, coagulation disorders, gestational toxicity, seizure No smoking, hookahs and drugs

Exclusion criteria

Exclusion criteria: Trying to perform spinal anesthesia more than once Failure of spinal anesthesia and other methods for anesthesia Having absolute rest more than 8 hours after surgery History of taking caffeine containing drugs The incidence of preoperative headache during the first 8 hours after surgery The presence of uncontrolled asthma in the patient Unwillingness to continue cooperation in the study Duration of surgery is more than 120 minutes

Design outcomes

Primary

MeasureTime frame
Blood pressure. Timepoint: Every 5 minutes to 30 minutes and then every 10 minutes until the end of surgery. Method of measurement: Barometer.;Heart rate. Timepoint: Every 5 minutes to 30 minutes and then every 10 minutes until the end of surgery. Method of measurement: count.;Percentage of oxygen saturation. Timepoint: Every 5 minutes to 30 minutes and then every 10 minutes until the end of surgery. Method of measurement: Percentage.;Headache. Timepoint: On the first, second, third, fifth and seventh days. Method of measurement: Visual analog scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Esmaeel Moshiri

Arak University of Medical Sciences

modir.he@gmail.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026