study of effect of local Tranexamic acid in reducing postoperative bleeding on ?coronary artery bypass graft ?

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141209020258N62

Enrollment

Registered

2018-01-17

Start date

2017-11-11

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary bypass graft. Atherosclerosis of coronary artery bypass graft(s), unspecified, with angina pectoris

Interventions

Intervention 1: Intervention group: Before the separation of the pulmonary pump, patients are treated with 2 gram of Tranexamic acid in 100 millileter and placed in the topical mediastinum of the pati

Treatment - Drugs

Intervention group: Before the separation of the pulmonary pump, patients are treated with 2 gram of Tranexamic acid in 100 millileter and placed in the topical mediastinum of the patient by the surge

Control group: Before the separation of the pulmonary pump, patients are treated with 100 millileter of normal saline and is topically injected into the mediastinum by the surgeon.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with elective CABG referrals ASA Class 2 and 3 Tranexamic acid insensitivity Surgery performed by a surgeon Duration of surgery 4 to 6 hours

Exclusion criteria

Exclusion criteria: Increase the duration of the operation for more than 6 hours cardiomegaly and CHF Going on a cardio-pulmonary pump for 2 times during operation All patients who die during surgery History of cardiac arrest and CPR before surgery

Design outcomes

Primary

Measure	Time frame
Bleeding after surgery. Timepoint: after surgery. Method of measurement: score.;Mean number of PACs received during 24 hours after surgery. Timepoint: 24 hours after surgery. Method of measurement: count.;Mean number of unit platelets received within 24 hours after surgery. Timepoint: 24 hours after surgery. Method of measurement: count.;Mean of number of FFP units received within 24 hours of surgery. Timepoint: 24 hours after surgery. Method of measurement: count.;The average number of returns to the operating room to control bleeding within 24 hours of operation. Timepoint: 24 hours after surgery. Method of measurement: count.	—

Measure

Time frame

Bleeding after surgery. Timepoint: after surgery. Method of measurement: score.;Mean number of PACs received during 24 hours after surgery. Timepoint: 24 hours after surgery. Method of measurement: count.;Mean number of unit platelets received within 24 hours after surgery. Timepoint: 24 hours after surgery. Method of measurement: count.;Mean of number of FFP units received within 24 hours of surgery. Timepoint: 24 hours after surgery. Method of measurement: count.;The average number of returns to the operating room to control bleeding within 24 hours of operation. Timepoint: 24 hours after surgery. Method of measurement: count.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Alireza rostami

Arak University of Medical Sciences

alikamaliir@yahoo.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026