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Comparative study of the effect of shiitake mushroom supplementation and a combination of vitamins C, D, and zinc on genital HPV infection

Comparative study of the effect of shiitake mushroom supplementation and a combination of vitamins C, D, and zinc on genital HPV infection

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20141209020258N203
Enrollment
66
Registered
2026-04-28
Start date
2026-05-05
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Human Papillomavirus. Cervical high risk human papillomavirus (HPV) DNA test positive

Interventions

Intervention 1: Control group: Patients received daily supplements including 220 mg of Zinc (Dana Pharma), 500 mg of Vitamin C (Donya Darou Pharmaceutical Co.), and 1000 IU of Vitamin D3 (Dana Pharma)

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
21 Years to 55 Years

Inclusion criteria

Inclusion criteria: Women with a positive HPV DNA test (PCR) Pap smear cytology report showing ASCUS or LSIL findings Women with no pregnancy or lactation No history of immunodeficiency Absence of a history of cone biopsy Absence of cardiac, renal, and hepatic disease No evidence of hepatitis B infection Absence of psychiatric or neurological disease Consent to participate in the study

Exclusion criteria

Exclusion criteria: Lack of cooperation

Design outcomes

Primary

MeasureTime frame
Cervical cytology status. Timepoint: Baseline and 6-month follow-up. Method of measurement: Pap smear.;HPV clearance. Timepoint: Baseline and 6-month follow-up. Method of measurement: Pap smear.;HPV genotype. Timepoint: Baseline and 6-month follow-up. Method of measurement: Pap smear.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Maryam Maktabi

Arak University of Medical Sciences

snikfar12@yahoo.com+98 86 3836 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026