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Comparison of droperidol and granisetron with dexamethasone and granisetron in the control of postoperative nausea and vomiting (PONV) in laparoscopic cholecystectomy

Comparison of droperidol and granisetron with dexamethasone and granisetron in the control of postoperative nausea and vomiting (PONV) in laparoscopic cholecystectomy

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20141209020258N202
Enrollment
120
Registered
2026-04-25
Start date
2026-04-19
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cholecystectomy surgery. Retained cholelithiasis following cholecystectomy

Interventions

Intervention 1: Intervention group 1: Patients will receive Granisetron (Caspian Tamin Rasht Pharmaceutical Company – Iran) at a dose of 20 micrograms per kilogram and 1.25 mg of Droperidol (Panpharma

Sponsors

Vice chancellor for research, Arak University Of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients who are candidates for laparoscopic cholecystectomy ASA class I or II both of gender Having informed consent to participate in the study Patients with no history of renal, hepatic, or cardiovascular disease Absence of any history of drug abuse, alcohol use, or chronic analgesic consumption Absence of a history of malignancy No history of hypertension, diabetes, or hematologic/vascular disorders No history of psychiatric or psychotic disorders No history of Parkinson’s disease, movement disorders, or chemotherapy No known sensitivity to study medications and no seasonal allergies All patients undergoing general anesthesia Surgery performed by a surgeon Surgical duration ranging from 60 to 150 minutes

Exclusion criteria

Exclusion criteria: Lack of consent to continue participation in the study Possible death of the patient

Design outcomes

Primary

MeasureTime frame
Incidence of nausea. Timepoint: Recovery and 2, 4, 6, 12 and 24 hours after surgery. Method of measurement: Score 0 to 10.;Vomiting. Timepoint: Recovery and 2, 4, 6, 12 and 24 hours after surgery. Method of measurement: Score 0 to 4.;Sedation. Timepoint: Recovery and 2, 4, 6, 12 and 24 hours after surgery. Method of measurement: Ramsay score.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Alireza Sosanabadi

Arak University of Medical Sciences

sosanabadi@arakmu.ac.ir+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026