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Comparison of the effect of adding magnesium sulfate,ketorolac, prostigmine and granistrone to lidocaine in reducing pain and hemodynamic changes in intravenous local anesthesia

Comparison of the effect of adding magnesium sulfate,ketorolac, prostigmine and granistrone to lidocaine in reducing pain and hemodynamic changes in intravenous local anesthesia

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20141209020258N195
Enrollment
295
Registered
2025-02-19
Start date
2025-02-19
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Forearm surgery. Unspecified acquired deformity of forearm

Interventions

Intervention 1: Intervention group 1: 10 mg/kg magnesium sulfate (50%) manufactured by Shahid Ghazi Tabriz Pharmaceutical Company will be used. Intervention 2: Intervention group 2: 2 mg granisetron (

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 65 Years

Inclusion criteria

Inclusion criteria: Both sexes Candidate for forearm surgery ASA class one and two No Raynaud's disease No sickle cell anemia No history of allergy to the drugs used in the study No cyanosis patient No use of narcotics and psychotropic drugs No contraindications to intravenous anesthesia No more than one fracture in the body or surgery No pregnancy No chronic pain syndrome No neurological disorders in the hand

Exclusion criteria

Exclusion criteria: If the duration of the surgery exceeds 90 minutes, these patients will be excluded from the study due to possible complications after opening the tourniquet that has been inflated for more than 90 minutes (due to the limitation on the time the tourniquet remains inflated). For any reason, intravenous local anesthesia wears off during the procedure (becomes ineffective). If the duration of the operation is less than 30 minutes, these patients will be excluded from the study due to possible complications after opening the tourniquet that has been in place for less than 30 minutes (due to the possibility of complications in opening the tourniquet earlier than 30 minutes).

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: After the tourniquet is inflated, and at times 15, 30, and 45, and every 15 minutes until the end of the surgery. Method of measurement: Visual analog scale of pain.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Shirin Pazuki

Arak University of Medical Sciences

pazuki@arakmu.ac.ir+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026