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The effect of melatonin in the treatment of delirium in critically ill patients admitted to the intensive care unit

The effect of melatonin in the treatment of delirium in critically ill patients admitted to the intensive care unit

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20141209020258N189
Enrollment
80
Registered
2023-09-25
Start date
2023-09-23
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delirium. Delirium due to known physiological condition

Interventions

Intervention 1: Intervention group 1: Patients in this group will receive 3 mg of melatonin at night for 5 days. Intervention 2: Intervention group 2: The patients in this group will receive haloperid

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: All patients for whom a diagnosis of delirium was made by DSM-criteria were included. Age 18 to 80 years RASS criterion greater than or equal to 3 Absence of primary neurological disease such as stroke, dementia, psychosis Failure to enter patients who are in a coma for more than 24 hours and have a structural reason for their low level of consciousness No history of seizures Absence of underlying disease The patient should not be so restless that there is a possibility of harming herself or others and she cannot wait for the response of oral medication. Absence of pregnancy and breastfeeding Insensitivity to drugs Absence of QTc greater than 440 ms No history of SSRI use

Exclusion criteria

Exclusion criteria: Lack of consent of the companions (the person in charge of the patient) to receive the medicine and the patient's participation in the study

Design outcomes

Primary

MeasureTime frame
Sedation. Timepoint: Daily to 7 days. Method of measurement: Based on the RASS score.;Illness severity. Timepoint: Daily to 7 days. Method of measurement: Apachi score.;Number of hospitalization days. Timepoint: End of study. Method of measurement: File.;Mortality. Timepoint: End of study. Method of measurement: File.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Hesamedin Modir

Arak University of Medical Sciences

modir.he@gmail.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026