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The effect of rocuronium and nitroglycerin in reducing pain in intravenous local anesthesia

Comparing the effect of adding rocuronium and nitroglycerin to ropivacaine in reducing pain and hemodynamic changes in intravenous local anesthesia

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20141209020258N183
Enrollment
177
Registered
2023-05-23
Start date
2023-06-05
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Forearm fracture. Other specified acquired deformities of forearm

Interventions

Intervention 1: Intervention group: The nitroglycerin group will be injected with 200 micrograms of nitroglycerin (Iran Caspin Company) along with 0.2% ropivacaine. The volume of ropivacaine in all gr

Sponsors

Vice chancellor for research, Arak University Of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 65 Years

Inclusion criteria

Inclusion criteria: 20-65 years ASA class I and II Forearm surgery candidate Consent to enter the study Not having Raynaud's disease Not having sickle cell anemia No history of allergy to the drugs used in the study Absence of cyanosis of the affected organ No use of drugs and psychotropic substances No contraindications for intravenous anesthesia The absence of more than one fracture in the body or surgery Absence of chronic pain syndrome Absence of neurological disorders in the hand

Exclusion criteria

Exclusion criteria: The duration of surgery is more than 90 minutes For any reason, the local intravenous anesthesia is terminated (ineffective) during the operation. The duration of the operation is less than 30 minutes

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: After filling the tourniquet, and at times 15, 30 and 45 and every 15 minutes until the end of the surgery, after emptying the tourniquet every 30 minutes up to 2 hours (minutes 30, 60, 90 and 120) and then every two hours until 12 hours (4, 6, 8, 10 and 12 hours) after emptying the tourniquet. Method of measurement: Visual analog scale of pain.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Esmaeel Moshiri

Arak University of Medical Sciences

modir.he@gmail.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026