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Comparison of intravenous injection and gargling of lidocaine and remifentanil mixture in attenuating hemodynamic responses and prevention of sore throat and cough after tracheal tube removal

Comparison of intravenous injection and gargling of lidocaine and remifentanil mixture in attenuating hemodynamic responses and prevention of sore throat and cough after tracheal tube removal

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20141209020258N172
Enrollment
76
Registered
2022-01-29
Start date
2022-02-04
Completion date
Unknown
Last updated
2022-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

General anesthesia.

Interventions

Intervention 1: First intervention group: 0.05 micrograms per kilogram of remifentanil is increased to 5 ml per patient, then 100 milligram of lidocaine (5 millileter of 2% lidocaine) (made by Caspia

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 60 Years

Inclusion criteria

Inclusion criteria: 30 to 60 years No history of sore throat before surgery No history of head and neck surgery, especially throat No history of drug use No history of chronic narcotic use Hypersensitivity to the drugs used in this study No upper airway infection and cold No malampati more than 2 Lack of liver and kidney failure No need to use NG-tube during surgery and up to 24 hours after surgery The duration of surgery should not be less than 45 minutes and not more than 120 minutes

Exclusion criteria

Exclusion criteria: Patient dissatisfaction to continue attending the study Observing blood during suctioning when the endotracheal tube is removed For any reason, we have to do laryngoscopy twice in the patient

Design outcomes

Primary

MeasureTime frame
Sore throat. Timepoint: In recovery, 2, 4, 8, 12 and 24 hours after surgery. Method of measurement: Visual Pain Questionnaire.;Cough. Timepoint: In recovery, 2, 4, 8, 12 and 24 hours after surgery. Method of measurement: Observation.;Hoarseness. Timepoint: In recovery, 2, 4, 8, 12 and 24 hours after surgery. Method of measurement: Observation.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Hesamedin Modir

Arak University of Medical Sciences

modir.he@gmail.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026