Comparison of the effect of ?Labetalol and Remifentanil and Dexmedetomidine in control of ?bleeding during head surgery

Comparison of the effect of?? ?Labetalol and Remifentanil and Dexmedetomidine in control of ?bleeding during Craniotomy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141209020258N167

Enrollment

Registered

2021-10-14

Start date

2021-10-23

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Craniotomy. Nontraumatic subarachnoid hemorrhage

Interventions

Intervention 1: ntervention group 1: A bolus dose of 10 millilitre of normal saline is administered for 10 minutes and then remifentanil is infused at a dose of 0.1 micro gram per kilogram per minute

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Age 18 to 75 years ASA Class One and Two No coagulation disorders No history of cardiovascular disease Proper control of blood pressure Absence of pregnancy Not addicted to opioids Body mass index more than 35 Candidate patients for craniotomy

Exclusion criteria

Exclusion criteria: Dissatisfaction Existence of allergy to the studied drugs Platelet count less than 150 thousand Family history of thromboembolism

Design outcomes

Primary

Measure	Time frame
Surgeon satisfaction. Timepoint: After surgery. Method of measurement: Question from the surgeon.;Bleeding. Timepoint: During surgery. Method of measurement: observation.;Mean hemoglobin. Timepoint: Before and 12 hours after surgery. Method of measurement: Hemoglobin blood test(CBC diff).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Esmaeel Moshiri

Arak University of Medical Sciences

modir.he@gmail.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026