Comparison of intravenous, local and oral Tranexamic Acid effect on reducing postoperative bleeding ?in coronary artery bypass graft surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141209020258N166

Enrollment

Registered

2021-10-03

Start date

2021-10-23

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery bypass graft surgery. Mechanical complication of coronary artery bypass graft and biological heart valve graft

Interventions

Intervention 1: Intervention group 1: One gram of Tranexamic Acid will be given orally (2 capsules of 500 mg with a glass of water). Intervention 2: Intervention group 2: 3 grams of Tranexamic Acid is

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All elective patients are candidates for coronary artery bypass graft surgery Lack of sensitivity to Tranexamic Acid

Exclusion criteria

Exclusion criteria: Death of patients Reluctance to participate in the study

Design outcomes

Primary

Measure	Time frame
Bleeding. Timepoint: Within 24 hours. Method of measurement: Observation.;Count of platelet received. Timepoint: Within 24 hours. Method of measurement: Count.;Number of fresh frozen plasma received. Timepoint: Within 24 hours. Method of measurement: Count.;Number of pack cell received. Timepoint: Within 24 hours. Method of measurement: Count.;Mortality. Timepoint: Within 72 hours. Method of measurement: Observation.	—

Measure

Time frame

Bleeding. Timepoint: Within 24 hours. Method of measurement: Observation.;Count of platelet received. Timepoint: Within 24 hours. Method of measurement: Count.;Number of fresh frozen plasma received. Timepoint: Within 24 hours. Method of measurement: Count.;Number of pack cell received. Timepoint: Within 24 hours. Method of measurement: Count.;Mortality. Timepoint: Within 72 hours. Method of measurement: Observation.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Behnam Mahmodie

Arak University of Medical Sciences

mahmodie@arakmu.ac.ir+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026