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Effect of midazolam, fentanyl and magnesium sulfate to on analgesia in knee ?arthroplasty

Comparison of addition of midazolam; fentanyl and magnesium sulfate to ?intrathecal bupivacaine on block characteristics and analgesia in knee ?arthroplasty

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20141209020258N164
Enrollment
105
Registered
2021-08-04
Start date
2021-04-09
Completion date
Unknown
Last updated
2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee arthroplasty. Presence of artificial knee joint

Interventions

Intervention 1: Intervention group1 : We will inject Midazolam at the dose of 2 milligram and hyperbar bupivacaine 0.5% at the dose of 15 milligram. Intervention 2: Intervention group 2: We will injec

Sponsors

Vice chancellor for research, Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Being at the age of 18 to 60 years ASA class 1 and 2 Patients who are candidates for knee replacement surgery

Exclusion criteria

Exclusion criteria: The patient refuses to perform spinal anesthesia Failure to perform spinal anesthesia Local infection in the spinal part Peripheral and central neuropathy Mental health problems Arrhythmia Coagulation disorders Cardiovascular problems

Design outcomes

Primary

MeasureTime frame
Sensory block duration. Timepoint: After surgery. Method of measurement: Chronometer.;Motor block duration. Timepoint: After surgery. Method of measurement: Chronometer.;Pain. Timepoint: Recovery and 2, 4, 6, 12 and 24 hours after surgery. Method of measurement: Visual analog pain questionnaire.;Mean of opiate drug use. Timepoint: 24 hours after surgery. Method of measurement: Milligram.;Mean blood pressure. Timepoint: Recovery and 2, 4 and 6 hours after surgery. Method of measurement: Sphygmomanometer.;Mean heart rate. Timepoint: Recovery and 2, 4 and 6 hours after surgery. Method of measurement: Count.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Esmaeel Moshiri

Arak University of Medical Sciences

modir.he@gmail.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 12, 2026