Comparison of Tranexamic Acid and Nitroglycerine and Remifentanil in prevention of bleeding during herniated lumbar intervertebral disc surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141209020258N159

Enrollment

135

Registered

2021-06-02

Start date

2021-06-15

Completion date

Unknown

Last updated

2021-06-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Herniated lumbar intervertebral disc. Other intervertebral disc displacement, lumbar region

Interventions

Intervention 1: Intervention group 1: We will be infusion a bolus dose of 10 milliliter of normal saline is administered for 10 minutes and then remifentanil is infused at a dose of 0.1 micrograms in

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age 18 to 60 years ASA class 1 and 2 No coagulation disorders No history of cardiovascular disease Proper control of blood pressure Absence of pregnancy Not addicted to opioids Body mass index more than 35 No family history of thromboembolism

Exclusion criteria

Exclusion criteria: Dissatisfaction with surgery Existence of allergy to the studied drugs Presence of plasma creatinine more than 1/5 Platelet count less than 150 thousand

Design outcomes

Primary

Measure	Time frame
Bleeding. Timepoint: During surgery. Method of measurement: Physical examination.;Surgeon consent. Timepoint: During surgery. Method of measurement: Observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Esmaeel Moshiri

Arak University of Medical Sciences

modir.he@gmail.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026