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Comparison of hemodynamic and antiemetic effects of midazolam combination with three drugs , ephedrine, dexamethasone and dexmedetomidine in patients undergoing laparoscopic cholecystectomy

Comparison of hemodynamic and antiemetic effects of midazolam combination with three drugs , ephedrine, dexamethasone and dexmedetomidine in patients undergoing laparoscopic cholecystectomy

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20141209020258N151
Enrollment
96
Registered
2021-02-21
Start date
2021-03-05
Completion date
Unknown
Last updated
2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cholecystectomy. Retained cholelithiasis following cholecystectomy

Interventions

Intervention 1: Intervention group 1: 0.5 mg / kg ephedrine will be prescribed. (Made by Biotica Pharmaceutical Company). Intervention 2: Intervention group 2: 0.05 mg / kg dexamethasone will be presc

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Candidate patients for laparoscopic cholecystectomy ASA class 1 and 2 No history of mental illness and psychosis No Parkinson's disease, motion sickness or history of chemotherapy Patients under general anesthesia Duration of surgery 60 to 150 minutes Lack of sensitivity to the drugs used No hypertension and no vascular problems

Exclusion criteria

Exclusion criteria: Patients without conscious consent Death of the patient

Design outcomes

Primary

MeasureTime frame
Incidence of nausea. Timepoint: Recovery and 2, 4, 6, 12 and 24 hours after surgery. Method of measurement: Observation.;Vomiting. Timepoint: Up to 24 hours after surgery. Method of measurement: Score 0 to 4.;Severe nausea. Timepoint: Up to 24 hours after surgery. Method of measurement: Visual analog scale.;Sedation. Timepoint: In recovery and 1, 2 and 4 hours after surgery. Method of measurement: Ramsay score.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Hesamedin Modir

Arak University of Medical Sciences

modir.he@gmail.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026