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Comparison of Dexmedetomidine , Lidocaine , Magnesium Sulfate and Remifentanil on cough suppression during tracheal tube removal

Comparison of Dexmedetomidine , Lidocaine , Magnesium Sulfate and Remifentanil on stimulatory responses and cough suppression during tracheal tube removal among patients under general anesthesia

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20141209020258N149
Enrollment
120
Registered
2020-09-23
Start date
2020-06-09
Completion date
Unknown
Last updated
2020-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

General anesthesia. Failed or difficult intubation

Interventions

Intervention 1: Intervention group 1: We infuse 0.5 microgram/kilogram Dexmedetomidine (Exir company, Tehran, Iran) slowly during 10 minutes. Intervention 2: Intervention group 2: We infuse 1.5 millig
Iran) slowly during 10 minutes. Intervention 3: Intervention group 3: We infuse 1 micro gram in kilogram Fentanyl (Normon,S.A company
Madrid
Spain) slowly in 10 minutes. Intervention 4: Intervention group 4: We infuse 30 milligram/kilogram magnesium sulphate 20% (Shahid Ghazi company, Tabriz, Iran) slowly during 10 minutes.

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age of 20 to 60 years ASA class 1 and 2 Malampati class ? and ?? Body mass index less than 30 The duration of surgery is between 60 and 120 minutes

Exclusion criteria

Exclusion criteria: Dissatisfaction of patients lung and heart disease Take cough medicines Active airway infection or having a history of surgery and pathology of the chin and larynx Esophageal sphincter insufficiency and (lack of reflux) Increased intracranial pressure and intraocular pressure

Design outcomes

Primary

MeasureTime frame
Cough. Timepoint: At the beginning of the study and then every 5 minutes to 40 minutes. Method of measurement: Observation.;Laryngospasm. Timepoint: At the beginning of the study and then every 5 minutes to 40 minutes. Method of measurement: Observation.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Esmaeel Moshiri

Arak University of Medical Sciences

modir.he@gmail.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026