Comparison of the effects of Ketamine and Propofol and Dexmedetomidine in treatment with electroconvulsive therapy in patients with depression

Comparison of the effects of Ketamine and Propofol and Dexmedetomidine in treatment with electroconvulsive therapy in patients with resistant to treatment major depressive disorder

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141209020258N143

Enrollment

Registered

2020-06-21

Start date

2020-01-20

Completion date

Unknown

Last updated

2020-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia. Schizophrenia

Interventions

Intervention 1: Intervention group 1: We inject 0.2 micro grams per kilogram Dexmedetomidine (Prizer-America) in 10 millilitre normal saline for 10 minute slowly. Intervention 2: Intervention group 2:

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 18 to 60 years Both sexes Patients with a diagnosis of schizophrenia

Exclusion criteria

Exclusion criteria: No history of drug use No pregnancy No history of cardiovascular disease (arrhythmias, ischemia, heart block) Do not take beta-blockers There are no contraindications to ECT, such as spinal cord injury and high ICP, and recent heart attacks.

Design outcomes

Primary

Measure	Time frame
Heart rate. Timepoint: Every 5 minutes. Method of measurement: Counting.;Mean blood pressure. Timepoint: Every 5 minutes. Method of measurement: Barometer.;Seizure duration. Timepoint: In times of seizures. Method of measurement: Minutes.;Patient satisfaction. Timepoint: After the shock. Method of measurement: Satisfaction Questionnaire.;Recovery duration. Timepoint: After the shock. Method of measurement: Minute.	—

Measure

Time frame

Heart rate. Timepoint: Every 5 minutes. Method of measurement: Counting.;Mean blood pressure. Timepoint: Every 5 minutes. Method of measurement: Barometer.;Seizure duration. Timepoint: In times of seizures. Method of measurement: Minutes.;Patient satisfaction. Timepoint: After the shock. Method of measurement: Satisfaction Questionnaire.;Recovery duration. Timepoint: After the shock. Method of measurement: Minute.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Behnam Mahmodie

Arak University of Medical Sciences

mahmodie@arakmu.ac.ir+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026