Management of opioid-induced pruritus after spinal anesthesia in femoral fracture surgery

Comparison of the effect of Midazolam, Dexamethasone, Ondansetron and Propofol in the prevention of opioid-induced pruritus after spinal anesthesia in femoral fracture surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141209020258N141

Enrollment

132

Registered

2020-04-09

Start date

2020-02-20

Completion date

Unknown

Last updated

2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Femoral fracture surgery. Fracture of femur

Interventions

Intervention 1: Intervention group1: We inject 4 milligram Ondansetron bolus followed by 50 millileter of distilled water with rate of 25 millileter per hour. Intervention 2: Intervention group 2: We

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age 18 to 65 years ASA class 1 and 2 Femoral fractures surgery No history of any skin condition associated with generalized itching No complaints of pruritus before surgery No history of drug addiction No history of seasonal allergies No history of long-term corticosteroid use Absence of motion sickness Absence of diabetes Absence of neuromuscular diseases

Exclusion criteria

Exclusion criteria: Failure in the anesthesia and use another method Dissatisfaction

Design outcomes

Primary

Measure	Time frame
Itching. Timepoint: During recovery and up to 12 hours after surgery, every 2 hours. Method of measurement: Observation.;Sedation. Timepoint: Every 15 minutes until the end of surgery and in recovery and then every 2 hours to 12 hours after surgery. Method of measurement: Ramsey score.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Esmaeel Moshiri

Arak University of Medical Sciences

modir.he@gmail.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026