Evaluation of the effect of Methylphenidate on consciousness in patients ?with brain damage in ICU

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141209020258N128

Enrollment

Registered

2020-01-10

Start date

2018-04-30

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain damage. Unspecified brain damage due to birth injury

Interventions

Intervention 1: Intervention group: Patients will receive 0.3 milligram in kilogram methylphenidate daily in two divided doses of 6 morning and 2 afternoon. Intervention 2: Control group: Patients wil

Eligibility

Sex/Gender

All

Age

16 Years to 50 Years

Inclusion criteria

Inclusion criteria: A level of consciousness less than 10 Being intuitive Ages between 16 and 50 years History of brain injury Absence of spacer lesion in brain scan (hematoma, tumor) No history of seizures No addiction to psychotropic substances and drugs No history of amphetamine use No history of hypertension, ischemic heart disease and diabetes mellitus Heart rate less than 120 times per minute

Exclusion criteria

Exclusion criteria: Seizure Arrhythmia Death

Design outcomes

Primary

Measure	Time frame
Level of consciousness. Timepoint: daily to clearance time. Method of measurement: Glasgow coma scale.;Illness severity. Timepoint: First and third day and time of discharge. Method of measurement: Apache score.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Alireza Kamali

Arak University of Medical Sciences

alikamaliir@yahoo.com+98 68 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026