Evaluation of the effect of Ketamine in the ventilator-free time in patients with agitated delirium compared with standard care

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141209020258N124

Enrollment

Registered

2019-11-25

Start date

2018-06-10

Completion date

Unknown

Last updated

2019-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delirium. Delirium due to known physiological condition

Interventions

Intervention 1: Intervention group: We will inject 1-2 milligram in hours Ketamine daily in ketamine group. Intervention 2: Control group: We will infusion Propofol in standard treatment group.

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 18 to 60 years No underlying disease: heart, brain, kidney, liver (encephalopathy) Richmond agitation-sedation scale more equal 3 No history of addiction to psychotropic drugs and drugs Absence of intracranial spacer lesion No history of seizures No seizures at admission No history of psychosis and personality disorder

Exclusion criteria

Exclusion criteria: 24 hours extubation tolerance Complications of ketamine medication Tachycardia

Design outcomes

Primary

Measure	Time frame
Agitation. Timepoint: At every shift to 24 hours after extubation. Method of measurement: Richmond Aghitation Sedation Score.;Pain. Timepoint: At every shift to 24 hours after extubation. Method of measurement: Visual analog scale questionnaire.;Intubation time. Timepoint: Before and after intervention. Method of measurement: Minute.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Alireza Kamali

Arak University of Medical Sciences

alikamaliir@yahoo.com+98 68 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026