Comparison of the efficacy and safety of administering of Tranexamic acid and Dexmedetomidine and Nitroglycerine in preventing bleeding and the quality of ?the surgical site during septorhinoplasty under general anesthesia

Comparison of the efficacy and safety of administering of Tranexamic acid and ?Dexmedetomidine and Nitroglycerine in preventing bleeding and the quality of ?the surgical site during septorhinoplasty under general anesthesia

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141209020258N121

Enrollment

105

Registered

2019-09-24

Start date

2019-03-06

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

septorhinoplasty. Nasal polyp

Interventions

Intervention 1: Intervention group: 1 micro gram per kilogram Dexmedetomidine during 15 minutes intravenously. Intervention 2: Intervention group: 10 milligram per kilogram Tranexamic acid during 15 m

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 18 to 60 years Suitable control for blood pressure No addiction to opioids Body mass index less than 35

Exclusion criteria

Exclusion criteria: Not having satisfaction to perform surgery Sensitivity to the drugs studied Need for prescribing low blood pressure drugs, in addition to those used in each group Coagulation disorders History of cardiovascular disease Pregnancy Chronic pulmonary disease(Asthma)

Design outcomes

Primary

Measure	Time frame
Mean arterial blood pressure. Timepoint: Every 15 minutes to end of surgery. Method of measurement: Digital sphygmomanometer.;Heart rate. Timepoint: Every 15 minutes to end of surgery. Method of measurement: ECG.;Percent of oxygen saturation. Timepoint: Every 15 minutes to end of surgery. Method of measurement: Pulse oximetry.;Recovery time. Timepoint: Recovery time. Method of measurement: Chronometer.;Duration of surgery. Timepoint: End of surgery. Method of measurement: chronometer.;Amount of Propofol consumed. Timepoint: End of surgery. Method of measurement: Milligram of drug in 24 hours.;Amount of bleeding. Timepoint: During surgery. Method of measurement: Observation.	—

Measure

Time frame

Mean arterial blood pressure. Timepoint: Every 15 minutes to end of surgery. Method of measurement: Digital sphygmomanometer.;Heart rate. Timepoint: Every 15 minutes to end of surgery. Method of measurement: ECG.;Percent of oxygen saturation. Timepoint: Every 15 minutes to end of surgery. Method of measurement: Pulse oximetry.;Recovery time. Timepoint: Recovery time. Method of measurement: Chronometer.;Duration of surgery. Timepoint: End of surgery. Method of measurement: chronometer.;Amount of Propofol consumed. Timepoint: End of surgery. Method of measurement: Milligram of drug in 24 hours.;Amount of bleeding. Timepoint: During surgery. Method of measurement: Observation.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Esmaeel Moshiri

Arak University of Medical Sciences

modir.he@gmail.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 15, 2026